A technique can determine for the first time how frequently, and exactly where, a molecular event called "backtracking" occurs throughout the genetic material (genome) of any species, a new study ...

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Backtracking refers to the retrograde movement of the RNA-dependent RNA polymerase (RdRp), which is the crucial enzyme within the SARS-CoV-2 replication-transcription complex. This enzyme comprises ...

The alternative text for this image may have been generated using AI. The presented structural snapshots of transcription intermediates reveal the mechanisms of Pol II backtracking, arrest and ...